Phenotypic analysis of human CD4+ T cells specific for immediate-early 63 protein of varicella-zoster virus.

Journal article

Open reading frame 63 of varicella-zoster Virus (VZV) encodes an immediate early (IE) phosphoprotein (IE63) that is believed to be important for viral infectivity and establishing latency. Evidence suggests that VZV-specific T cells are crucial in the control of viral replication; however, data addressing the existence of IE63 protein-specific CD4+ T cells are limited. Using IFN-gamma immunosorbent assays, we identified high frequencies of responses to overlapping peptides spanning the IE63 p...

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Authors: Jones, L; Black, A; Malavige, G; Ogg, G

• Publication status: Published
• Journal: European journal of immunology
• Volume: 37
• Issue: 12
• Pages: 3393-3403
• Publication date: 2007-12-01
• DOI: 10.1002/eji.200737648
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: CD4-Positive T-Lymphocytes; Epitopes; HLA-DR Antigens; Antigen Presentation; Immediate-Early Proteins; Herpesvirus 3, Human; Cells, Cultured; Molecular Sequence Data; Keratinocytes; Adult; Immunophenotyping; T-Lymphocyte Subsets; Male; Antigens, Viral; Immunologic Memory; HLA-DRB1 Chains; Peptide Fragments; Virus Activation; Amino Acid Sequence; Female; T-Cell Antigen Receptor Specificity; Viral Envelope Proteins; Humans