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Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site.

Abstract:

Treatment of latent tuberculosis infection remains an important goal of global TB eradication. To this end, targets that are essential for intracellular survival of Mycobacterium tuberculosis are particularly attractive. Arylamine N-acetyltransferase (NAT) represents such a target as it is, along with the enzymes encoded by the associated gene cluster, essential for mycobacterial survival inside macrophages and involved in cholesterol degradation. Cholesterol is likely to be the fuel for M. t...

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Publication status:
Published

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Publisher copy:
10.1007/s13238-010-0037-7

Authors


Abuhammad, AM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
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Publisher:
Higher Education Press
Journal:
Protein and cell
Volume:
1
Issue:
4
Pages:
384-392
Publication date:
2010-04-05
DOI:
EISSN:
1674-8018
ISSN:
1674-800X
URN:
uuid:a83e0e64-c9a7-4818-8434-80dcc9e85608
Source identifiers:
110207
Local pid:
pubs:110207

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