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Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site.

Abstract:

Treatment of latent tuberculosis infection remains an important goal of global TB eradication. To this end, targets that are essential for intracellular survival of Mycobacterium tuberculosis are particularly attractive. Arylamine N-acetyltransferase (NAT) represents such a target as it is, along with the enzymes encoded by the associated gene cluster, essential for mycobacterial survival inside macrophages and involved in cholesterol degradation. Cholesterol is likely to be the fuel for M. t...

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Publication status:
Published

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Publisher copy:
10.1007/s13238-010-0037-7

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Publisher:
Higher Education Press
Journal:
Protein and cell
Volume:
1
Issue:
4
Pages:
384-392
Publication date:
2010-04-01
DOI:
EISSN:
1674-8018
ISSN:
1674-800X
Source identifiers:
110207
Language:
English
Keywords:
Pubs id:
pubs:110207
UUID:
uuid:a83e0e64-c9a7-4818-8434-80dcc9e85608
Local pid:
pubs:110207
Deposit date:
2012-12-19

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