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Conformational dynamics of a lipid-interacting protein: MD simulations of saposin B.

Abstract:

Saposin B is a water soluble alpha-helical protein which can bind to membranes and extract selected lipids, especially cerebroside sulfates. The X-ray structure of saposin B is homodimeric. There are two conformations of the dimer in the crystal-one with a closed central cavity (the AB dimer) and one (the CD dimer) with a more open cavity. We have conducted a series of short (5 ns) molecular dynamics simulations of saposin B, starting from both the AB and CD conformations and with/without bou...

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Publication status:
Published

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Publisher copy:
10.1021/bi701320a
Journal:
Biochemistry More from this journal
Volume:
46
Issue:
47
Pages:
13573-13580
Publication date:
2007-11-01
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
Language:
English
Keywords:
Pubs id:
pubs:100790
UUID:
uuid:a82dc52b-bb2f-4ec5-895f-dc16d7ddce12
Local pid:
pubs:100790
Source identifiers:
100790
Deposit date:
2012-12-19

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