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Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar.

Abstract:

In mammalian systems, the heterodimeric basic helix-loop-helix (bHLH)-PAS transcription hypoxia-inducible factor (HIF) has emerged as the key regulator of responses to hypoxia. Here we define a homologous system in Drosophila melanogaster, and we characterize its activity in vivo during development. By using transcriptional reporters in developing transgenic flies, we show that hypoxia-inducible activity rises to a peak in late embryogenesis and is most pronounced in tracheal cells. We show t...

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Publication status:
Published

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Journal:
Molecular and cellular biology More from this journal
Volume:
22
Issue:
19
Pages:
6842-6853
Publication date:
2002-10-01
DOI:
EISSN:
1098-5549
ISSN:
0270-7306

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