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Identification of thyroid stimulating hormone receptor-specific T cells in Graves' disease thyroid using autoantigen-transfected Epstein-Barr virus-transformed B cell lines.

Abstract:

The importance of thyrotropin receptor (TSHR) agonist antibodies in the manifestations of Graves' disease (GD) is recognized. There are, however, no convincing reports of TSHR-specific T cells. We have previously cloned T cells specific for thyroglobulin and thyroid peroxidase (TPO) from GD lymphoid infiltrates and used autologous EBV-transformed B cell lines (EBVL) transfected with an expression vector encoding TPO to efficiently detect TPO-specific T cells. Here we used EBVL transfected wit...

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Publication status:
Published

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Publisher copy:
10.1172/jci118034

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Journal:
The Journal of clinical investigation
Volume:
96
Issue:
1
Pages:
30-37
Publication date:
1995-07-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:a82b2329-7dfe-4540-a8b7-b5488f7f9171
Source identifiers:
481641
Local pid:
pubs:481641

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