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Stem cell biology is population biology: differentiation of hematopoietic multipotent progenitors to common lymphoid and myeloid progenitors.

Abstract:

The hematopoietic stem cell (HSC) system is a demand control system, with the demand coming from the organism, since the products of the common myeloid and lymphoid progenitor (CMP, CLP respectively) cells are essential for activity and defense against disease. We show how ideas from population biology (combining population dynamics and evolutionary considerations) can illuminate the feedback control of the HSC system by the fully differentiated products, which has recently been verified expe...

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Publication status:
Published

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Publisher copy:
10.1186/1742-4682-10-5

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
Journal:
Theoretical biology and medical modelling More from this journal
Volume:
10
Issue:
1
Pages:
5
Publication date:
2013-01-01
DOI:
EISSN:
1742-4682
ISSN:
1742-4682
Language:
English
Keywords:
Pubs id:
pubs:374293
UUID:
uuid:a82b1386-7988-4672-a401-db1ff86bed0e
Local pid:
pubs:374293
Source identifiers:
374293
Deposit date:
2013-11-16

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