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Markers of glutamate synaptic transmission and plasticity are increased in the anterior cingulate cortex in bipolar disorder.

Abstract:

BACKGROUND: Cortical glutamate levels are elevated in bipolar disorder, but the interpretation of this increase is unclear because glutamate has metabolic as well as neurotransmitter roles. We investigated this by measuring vesicular glutamate transporter 1 (VGluT1) expression, which reflects activity at glutamate synapses. We also measured netrin-G1 and netrin-G2 messenger RNAs because these genes are involved in the formation and plasticity of glutamatergic connections. METHODS: Using quan...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
Journal:
Biological psychiatry More from this journal
Volume:
67
Issue:
11
Pages:
1010-1016
Publication date:
2010-06-01
DOI:
EISSN:
1873-2402
ISSN:
0006-3223

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