Markers of glutamate synaptic transmission and plasticity are increased in the anterior cingulate cortex in bipolar disorder.

Journal article

BACKGROUND: Cortical glutamate levels are elevated in bipolar disorder, but the interpretation of this increase is unclear because glutamate has metabolic as well as neurotransmitter roles. We investigated this by measuring vesicular glutamate transporter 1 (VGluT1) expression, which reflects activity at glutamate synapses. We also measured netrin-G1 and netrin-G2 messenger RNAs because these genes are involved in the formation and plasticity of glutamatergic connections. METHODS: Using quan...

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Authors: Eastwood, S; Harrison, P

• Publication status: Published
• Journal: Biological psychiatry
• Volume: 67
• Issue: 11
• Pages: 1010-1016
• Publication date: 2010-06-01
• DOI: 10.1016/j.biopsych.2009.12.004
• EISSN: 1873-2402
• ISSN: 0006-3223
• Language: English
• Keywords: Gyrus Cinguli; GPI-Linked Proteins; Schizophrenia; Analysis of Variance; Glycoproteins; Aged; Functional Laterality; Neurons; Humans; Genotype; Neuronal Plasticity; In Situ Hybridization; Female; Middle Aged; Nerve Tissue Proteins; Bipolar Disorder; Reverse Transcriptase Polymerase Chain Reaction; Presynaptic Terminals; Synaptic Transmission; Vesicular Glutamate Transport Protein 1; Glutamic Acid; Adult; Male