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Chemotherapeutic options in chronic lymphocytic leukemia: a meta-analysis of the randomized trials. CLL Trialists' Collaborative Group.

Abstract:

BACKGROUND: The randomized trials that evaluate the timing and intensity of initial chemotherapy for chronic lymphocytic leukemia (CLL) have, in general, been too small to provide separately reliable results. We compared the effects on survival of the following: a) immediate versus deferred chemotherapy for early-stage CLL and b) combination chemotherapy (e.g., cyclophosphamide and vincristine plus prednisone/prednisolone [COP] or COP plus doxorubicin [CHOP]) versus single-agent chlorambucil...

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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
Journal:
Journal of the National Cancer Institute More from this journal
Volume:
91
Issue:
10
Pages:
861-868
Publication date:
1999-05-01
EISSN:
1460-2105
ISSN:
0027-8874
Language:
English
Keywords:
Pubs id:
pubs:96020
UUID:
uuid:a81d583d-db39-4b32-920b-0cb84ddc900f
Local pid:
pubs:96020
Source identifiers:
96020
Deposit date:
2012-12-19

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