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Chemotherapeutic options in chronic lymphocytic leukemia: a meta-analysis of the randomized trials. CLL Trialists' Collaborative Group.

Abstract:

BACKGROUND: The randomized trials that evaluate the timing and intensity of initial chemotherapy for chronic lymphocytic leukemia (CLL) have, in general, been too small to provide separately reliable results. We compared the effects on survival of the following: a) immediate versus deferred chemotherapy for early-stage CLL and b) combination chemotherapy (e.g., cyclophosphamide and vincristine plus prednisone/prednisolone [COP] or COP plus doxorubicin [CHOP]) versus single-agent chlorambucil...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
Journal:
Journal of the National Cancer Institute
Volume:
91
Issue:
10
Pages:
861-868
Publication date:
1999-05-05
EISSN:
1460-2105
ISSN:
0027-8874
URN:
uuid:a81d583d-db39-4b32-920b-0cb84ddc900f
Source identifiers:
96020
Local pid:
pubs:96020

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