Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells.

Journal article

CD4(+)CD25(+) regulatory T cells (Treg) have been described as an important hurdle for immunotherapy. Engagement of glucocorticoid-induced TNF receptor-related protein (GITR) has emerged recently as an important mechanism to control the suppression of CD4(+)CD25(+) Treg. Furthermore, it has been documented extensively that GITR ligation is costimulatory for naive and activated T cells in the murine setting. However, little is known about the role of the human GITR ligand (huGITRL). We wanted ...

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Authors: Tuyaerts, S; Van Meirvenne, S; Bonehill, A; Heirman, C; Corthals, J

• Publication status: Published
• Journal: Journal of leukocyte biology
• Volume: 82
• Issue: 1
• Pages: 93-105
• Publication date: 2007-07-01
• DOI: 10.1189/jlb.0906568
• EISSN: 1938-3673
• ISSN: 0741-5400
• Language: English
• Keywords: Endothelium, Vascular; Dendritic Cells; Myeloid Cells; Cells, Cultured; T-Cell Antigen Receptor Specificity; Tumor Necrosis Factors; Umbilical Cord; Humans; Antigen Presentation; T-Lymphocytes, Regulatory; Immunity; Electroporation