Journal article icon

Journal article

Chlorproguanil/dapsone for uncomplicated Plasmodium falciparum malaria in young children: pharmacokinetics and therapeutic range.

Abstract:

The disposition of chlorproguanil/dapsone (one daily dose for 3 d of 1.2 and 2.4 mg/kg respectively) has been studied in young children with Plasmodium falciparum malaria, to provide data complementary to a clinical trial of this drug combination. Unbound concentrations of chlorcycloguanil (the active metabolite of chlorproguanil) and dapsone in clinical samples have been related to the unbound drug concentrations which produced defined outcomes in tests in vitro of drug efficacy and toxicity...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume:
91
Issue:
3
Pages:
322-327
Publication date:
1997-01-01
DOI:
EISSN:
1878-3503
ISSN:
0035-9203
URN:
uuid:a808cfee-9401-4c26-a759-acaf8d614616
Source identifiers:
45611
Local pid:
pubs:45611

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP