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The hemochromatosis protein HFE inhibits iron export from macrophages.

Abstract:

Hereditary hemochromatosis (HH) is a disorder of iron metabolism caused by common mutations in the gene HFE. The HFE protein binds to transferrin receptor-1 (TfR1) in competition with transferrin, and in vitro, reduces cellular iron by reducing iron uptake. However, in vivo, HFE is strongly expressed by liver macrophages and intestinal crypt cells, which behave as though they are relatively iron-deficient in HH. These latter observations suggest, paradoxically, that expression of wild-type HF...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.242614699

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Institution:
University of Oxford
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
99
Issue:
24
Pages:
15602-15607
Publication date:
2002-11-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
30065

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