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The hemochromatosis protein HFE inhibits iron export from macrophages.

Abstract:

Hereditary hemochromatosis (HH) is a disorder of iron metabolism caused by common mutations in the gene HFE. The HFE protein binds to transferrin receptor-1 (TfR1) in competition with transferrin, and in vitro, reduces cellular iron by reducing iron uptake. However, in vivo, HFE is strongly expressed by liver macrophages and intestinal crypt cells, which behave as though they are relatively iron-deficient in HH. These latter observations suggest, paradoxically, that expression of wild-type HF...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.242614699

Authors


Drakesmith, H More by this author
Sweetland, E More by this author
Schimanski, L More by this author
More by this author
Institution:
University of Oxford
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
99
Issue:
24
Pages:
15602-15607
Publication date:
2002-11-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:a8075516-ec1a-4062-bfaa-0555ffe1cede
Source identifiers:
30065
Local pid:
pubs:30065

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