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Conformational changes and gating at the selectivity filter of potassium channels.

Abstract:

The translocation of ions and water across cell membranes is a prerequisite for many of life's processes. K(+) channels are a diverse family of integral membrane proteins through which K(+) can pass selectively. There is an ongoing debate about the nature of conformational changes associated with the opening and closing and conductive and nonconductive states of potassium (K(+)) channels. These changes depend on the membrane potential, the K(+) concentration gradient, and large scale motions ...

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Publication status:
Published

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Publisher copy:
10.1021/ja801792g
Journal:
Journal of the American Chemical Society More from this journal
Volume:
130
Issue:
29
Pages:
9474-9480
Publication date:
2008-07-01
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
Language:
English
Keywords:
Pubs id:
pubs:118288
UUID:
uuid:a8053b56-8567-4b47-ac63-0aab2674f589
Local pid:
pubs:118288
Source identifiers:
118288
Deposit date:
2012-12-19

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