Low-level microsatellite instability occurs in most colorectal cancers and is a nonrandomly distributed quantitative trait.

Journal article

About 10-15% of colorectal cancers show high-level microsatellite instability. The characteristics and very existence of low-level instability (MSI-L) are unclear, although some studies have found associations between MSI-L and molecular characteristics, notably more frequent K-ras mutations and a low level of allele loss near APC. We have attempted to define a MSI-L group of tumors by analyzing 107 sporadic colorectal carcinomas at 44 microsatellites. Ten (9.7%) MSI-H cancers were identified...

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Authors: Halford, S; Sasieni, P; Rowan, A; Wasan, H; Bodmer, W

• Publication status: Published
• Journal: Cancer research
• Volume: 62
• Issue: 1
• Pages: 53-57
• Publication date: 2002-01-01
• EISSN: 1538-7445
• ISSN: 0008-5472
• Language: English
• Keywords: Microsatellite Repeats; Humans; Colorectal Neoplasms; Quantitative Trait, Heritable; Loss of Heterozygosity