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Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13.

Abstract:

In genome-wide association studies (GWASs) of colorectal cancer, we have identified two genomic regions in which pairs of tagging-single nucleotide polymorphisms (tagSNPs) are associated with disease; these comprise chromosomes 1q41 (rs6691170, rs6687758) and 12q13.13 (rs7163702, rs11169552). We investigated these regions further, aiming to determine whether they contain more than one independent association signal and/or to identify the SNPs most strongly associated with disease. Genotyping ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/hmg/ddr523

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
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Funding agency for:
Carvajal-Carmona, LG
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Funding agency for:
Tomlinson, IP
Cancer Research UK More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Human molecular genetics Journal website
Volume:
21
Issue:
4
Pages:
934-946
Publication date:
2012-02-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:a7fa476e-51e4-4877-bab8-ea889ffde17a
Source identifiers:
272112
Local pid:
pubs:272112

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