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Thesis

Loss of chaperone protein in human cancer

Abstract:

TRAP1 is a Heat Shock Protein (HSP) chaperone to retinoblastoma but also associated to the tumor necrosis factor receptor. HSPs are primarily up regulated in cancer. Work in our lab noted a down regulation of TRAP1 in some non-small cell lung cancers compared to normal lung. The first aim of this project was to evaluate the effect of the loss of TRAP1 on cell proliferation using a spheroid model. The presence of TRAP1 in spheroids promoted cell proliferation and a faster onset of hypoxia. ...

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Institution:
University of Oxford
Research group:
CRUK Tumour Pathology
Oxford college:
St Cross College
Department:
Medical Sciences Division - Clinical Laboratory Sciences

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:a7f45bfa-50ec-41d1-935b-d71a29f0ffac
Local pid:
ora:7077

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