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Semaphorin-7A Is an Erythrocyte Receptor for P. falciparum Merozoite-Specific TRAP Homolog, MTRAP

Abstract:

The motility and invasion of Plasmodium parasites is believed to require a cytoplasmic actin-myosin motor associated with a cell surface ligand belonging to the TRAP (thrombospondin-related anonymous protein) family. Current models of invasion usually invoke the existence of specific receptors for the TRAP-family ligands on the surface of the host cell; however, the identities of these receptors remain largely unknown. Here, we identify the GPI-linked protein Semaphorin-7A (CD108) as an eryth...

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Publication status:
Published

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Publisher copy:
10.1371/journal.ppat.1003031

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Journal:
PLoS Pathogens
Volume:
8
Issue:
11
Pages:
e1003031
Publication date:
2012-01-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Source identifiers:
365828
Language:
English
Keywords:
UUID:
uuid:a7eec751-059d-493c-a39b-60b93a1b1e4b
Local pid:
pubs:365828
Deposit date:
2013-11-16

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