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Orbitofrontal connectivity with resting-state networks is associated with midbrain dopamine D3 receptor availability.

Abstract:

Animal research and human postmortem evidence highlight the importance of brain dopamine D3 receptor (D3R) function in multiple neuropsychiatric disorders, including addiction. Separate anatomical and functional neuroimaging findings implicate disrupted frontal cortical connectivity with distributed brain networks in processes relevant for these diseases. This potential conjunction between molecular and functional markers has not, however, been tested directly. Here, we used a novel combinati...

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Publication status:
Published

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Publisher copy:
10.1093/cercor/bhr354

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Beckmann, CF More by this author
Searle, GE More by this author
Plisson, C More by this author
Tziortzi, AC More by this author
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Journal:
Cerebral cortex (New York, N.Y. : 1991)
Volume:
22
Issue:
12
Pages:
2784-2793
Publication date:
2012-12-05
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
URN:
uuid:a7e60797-5cbf-46eb-8e32-70078d4865b2
Source identifiers:
375487
Local pid:
pubs:375487

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