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Orbitofrontal connectivity with resting-state networks is associated with midbrain dopamine D3 receptor availability.

Abstract:

Animal research and human postmortem evidence highlight the importance of brain dopamine D3 receptor (D3R) function in multiple neuropsychiatric disorders, including addiction. Separate anatomical and functional neuroimaging findings implicate disrupted frontal cortical connectivity with distributed brain networks in processes relevant for these diseases. This potential conjunction between molecular and functional markers has not, however, been tested directly. Here, we used a novel combinati...

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Publication status:
Published

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Publisher copy:
10.1093/cercor/bhr354

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Journal:
Cerebral cortex (New York, N.Y. : 1991)
Volume:
22
Issue:
12
Pages:
2784-2793
Publication date:
2012-12-01
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
Source identifiers:
375487
Language:
English
Keywords:
Pubs id:
pubs:375487
UUID:
uuid:a7e60797-5cbf-46eb-8e32-70078d4865b2
Local pid:
pubs:375487
Deposit date:
2013-11-16

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