Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever.

Journal article

Responses by peripheral blood leukocytes may contribute to the pathogenesis of dengue hemorrhagic fever (DHF). We used DNA microarrays to reveal transcriptional patterns in the blood of 14 adults with DHF. Acute DHF was defined by an abundance of transcripts from cell cycle- and endoplasmic reticulum (ER)-related genes, suggesting a proliferative response accompanied by ER stress. Transcript-abundance levels for immunoresponse-associated genes, including cell surface markers, immunoglobulin, ...

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Authors: Simmons, C; Popper, S; Dolocek, C; Chau, T; Griffiths, M

• Publication status: Published
• Journal: Journal of infectious diseases
• Volume: 195
• Issue: 8
• Pages: 1097-1107
• Publication date: 2007-04-01
• DOI: 10.1086/512162
• EISSN: 1537-6613
• ISSN: 0022-1899
• Language: English
• Keywords: Dengue Virus; Adult; CD4-Positive T-Lymphocytes; Cytokines; Transcription, Genetic; CD8-Positive T-Lymphocytes; Male; Genes, cdc; DNA Primers; Child; Oligonucleotide Array Sequence Analysis; Severe Dengue; RNA, Viral; Gene Expression Regulation, Viral; B-Lymphocytes; Adolescent; Acute Disease; Gene Expression Profiling; RNA, Messenger; Convalescence; Vietnam; Humans; Female; Multigene Family