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The effects of mosquito transmission and population bottlenecking on virulence, multiplication rate and rosetting in rodent malaria.

Abstract:

Malaria parasites vary in virulence, but the effects of mosquito transmission on virulence phenotypes have not been systematically analysed. Using six lines of malaria parasite that varied widely in virulence, three of which had been serially blood-stage passaged many times, we found that mosquito transmission led to a general reduction in malaria virulence. Despite that, the between-line variation in virulence remained. Forcing serially passaged lines through extreme population bottlenecks (...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Journal:
International journal for parasitology
Volume:
35
Issue:
2
Pages:
145-153
Publication date:
2005-02-01
DOI:
EISSN:
1879-0135
ISSN:
0020-7519
Source identifiers:
90497
Language:
English
Keywords:
Pubs id:
pubs:90497
UUID:
uuid:a7e1bb2a-5260-4fdb-94db-9fd25be35cc2
Local pid:
pubs:90497
Deposit date:
2012-12-19

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