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Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin

Abstract:

Iron is critical for life but toxic in excess because of iron-catalysed formation of pro-oxidants that cause tissue damage in a range of disorders. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) orchestrates cell-intrinsic protective antioxidant responses, while the peptide hormone hepcidin maintains systemic iron homoeostasis, but is pathophysiologically decreased in haemochromatosis and β-thalassaemia. Here, we show that Nrf2 is activated by iron-induced, mitoch...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s42255-019-0063-6

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
ORCID:
0000-0002-8503-6103
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Name:
Medical Research Council
Grant:
4050630002
Publisher:
Springer Nature
Journal:
Nature Metabolism More from this journal
Volume:
1
Issue:
2019
Pages:
519-531
Publication date:
2019-05-13
Acceptance date:
2019-04-05
DOI:
EISSN:
2522-5812
Keywords:
Pubs id:
pubs:994916
UUID:
uuid:a7de86ab-63a8-484f-a6a2-f9a6fff9734a
Local pid:
pubs:994916
Source identifiers:
994916
Deposit date:
2019-04-29

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