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Estimating individual exposure to malaria using local prevalence of malaria infection in the field.

Abstract:

BACKGROUND: Heterogeneity in malaria exposure complicates survival analyses of vaccine efficacy trials and confounds the association between immune correlates of protection and malaria infection in longitudinal studies. Analysis may be facilitated by taking into account the variability in individual exposure levels, but it is unclear how exposure can be estimated at an individual level. METHOD AND FINDINGS: We studied three cohorts (Chonyi, Junju and Ngerenya) in Kilifi District, Kenya to ass...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0032929

Authors


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Institution:
University of Oxford
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Marsh, K
Grant:
077176
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Name:
Medical Research Council
Funding agency for:
Bejon, P
Publisher:
Public Library of Science
Journal:
PloS one More from this journal
Volume:
7
Issue:
3
Article number:
e32929
Publication date:
2012-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203

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