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CBP/p300 bromodomains regulate amyloid-like protein aggregation upon aberrant lysine acetylation

Abstract:

Lysine acetylation is becoming increasingly recognized as a general biological principle in cellular homeostasis, and is subject to abnormal control in different human pathologies. Here, we describe a global effect on amyloid-like protein aggregation in human cells that results from aberrant lysine acetylation. Bromodomain reader proteins are involved in the aggregation process and, using chemical biology and gene silencing, we establish that p300/CBP bromodomains are necessary for aggregatio...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.chembiol.2016.11.009

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Eurocan Platform More from this funder
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Funding agency for:
Olzscha, H
More from this funder
Funding agency for:
Olzscha, H
Publisher:
Cell Press Publisher's website
Journal:
Cell Chemical Biology Journal website
Volume:
24
Issue:
1
Pages:
9–23
Publication date:
2016-12-10
Acceptance date:
2016-11-15
DOI:
ISSN:
2451-9456
Language:
English
Keywords:
Pubs id:
pubs:667266
UUID:
uuid:a7ce66df-21a2-40e1-b97f-28c9c5bfc44e
Local pid:
pubs:667266
Deposit date:
2017-01-18

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