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Plant-made polio type 3 stabilized VLPs-a candidate synthetic polio vaccine.

Abstract:

Poliovirus (PV) is the causative agent of poliomyelitis, a crippling human disease known since antiquity. PV occurs in two distinct antigenic forms, D and C, of which only the D form elicits a robust neutralizing response. Developing a synthetically produced stabilized virus-like particle (sVLP)-based vaccine with D antigenicity, without the drawbacks of current vaccines, will be a major step towards the final eradication of poliovirus. Such a sVLP would retain the native antigenic conformati...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-017-00090-w

Authors


Marsian, J More by this author
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Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Department:
Oxford, MSD, NDM, Structural Biology
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Department:
Oxford, MSD, NDM, Structural Biology
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John Innes Foundation More from this funder
World Health Organisation More from this funder
Bill and Melinda Gates Foundation More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Issue:
1
Pages:
245
Publication date:
2017-08-05
Acceptance date:
2017-05-31
DOI:
EISSN:
2041-1723
Pubs id:
pubs:724088
URN:
uri:a7cac6c4-ed02-4fdb-9931-246a68409e26
UUID:
uuid:a7cac6c4-ed02-4fdb-9931-246a68409e26
Local pid:
pubs:724088
Language:
English
Keywords:

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