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Epstein-Barr virus but not cytomegalovirus is associated with reduced vaccine antibody responses in Gambian infants.

Abstract:

BACKGROUND: Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are persistent herpesviruses that have various immunomodulatory effects on their hosts. Both viruses are usually acquired in infancy in Sub-Saharan Africa, a region where childhood vaccines are less effective than in high income settings. To establish whether there is an association between these two observations, we tested the hypothesis that infection with one or both viruses modulate antibody responses to the T-cell independent...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0014013

Authors


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Medical Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
5
Issue:
11
Pages:
e14013
Publication date:
2010-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
176646

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