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A linear complexity phasing method for thousands of genomes

Abstract:
Human-disease etiology can be better understood with phase information about diploid sequences. We present a method for estimating haplotypes, using genotype data from unrelated samples or small nuclear families, that leads to improved accuracy and speed compared to several widely used methods. The method, segmented haplotype estimation and imputation tool (SHAPEIT), scales linearly with the number of haplotypes used in each iteration and can be run efficiently on whole chromosomes. © 2012 Nature America, Inc. All rights reserved.

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Publisher copy:
10.1038/nmeth.1785

Authors


Delaneau, O More by this author
Marchini, J More by this author
Zagury, J-F More by this author
Journal:
Nature Methods
Volume:
9
Issue:
2
Pages:
179-181
Publication date:
2012-02-05
DOI:
EISSN:
1549-1676
ISSN:
1548-7091
URN:
uuid:a7ae3114-8d7d-4fb7-aa33-1961ba54125e
Source identifiers:
313841
Local pid:
pubs:313841
Language:
English

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