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Journal article

Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes.

Abstract:

Arginase 1, via competing with nitric oxide (NO) synthase for the substrate L-arginine, may interfere with NO-mediated vascular responses. We tested the hypothesis that arginase 1 contributes to coronary vasomotor dysfunction in patients with diabetes mellitus (DM). Coronary arterioles were dissected from the right atrial appendages of 41 consecutive patients with or without DM (the 2 groups suffered from similar comorbidities), and agonist-induced changes in diameter were measured with video...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.00831.2010

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
300
Issue:
3
Pages:
H777-H783
Publication date:
2011-03-01
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
Source identifiers:
164541
Language:
English
Keywords:
Pubs id:
pubs:164541
UUID:
uuid:a7a6e609-885c-4bba-a3eb-4685e29b4743
Local pid:
pubs:164541
Deposit date:
2012-12-19

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