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The two activation domains of the Brn-3a transcription factor have distinct functional properties

Abstract:

The Brn-3a transcription factor has two distinct activation domains located, respectively, at the N-terminus and the C-terminus (coincident with the DNA binding POU domain) which differ in their effects on different target promoters. To analyze whether these regions could function when linked to a heterologous DNA binding domain, they were each linked to the GAL4 DNA binding domain. Here we show that the N-terminal domain constitutes a discrete activation domain which can function when linked...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
INTERNATIONAL JOURNAL OF BIOCHEMISTRY and CELL BIOLOGY
Volume:
29
Issue:
12
Pages:
1493-1500
Publication date:
1997-12-05
DOI:
ISSN:
1357-2725
URN:
uuid:a7a38201-851b-4c0c-85e6-cf687d3d74e7
Source identifiers:
114420
Local pid:
pubs:114420

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