Journal article icon

Journal article

Functional epistasis on a common MHC haplotype associated with multiple sclerosis.

Abstract:

Genes in the major histocompatibility complex (MHC) encode proteins important in activating antigen-specific immune responses. Alleles at adjacent MHC loci are often in strong linkage disequilibrium; however, little is known about the mechanisms responsible for this linkage disequilibrium. Here we report that the human MHC HLA-DR2 haplotype, which predisposes to multiple sclerosis, shows more extensive linkage disequilibrium than other common caucasian HLA haplotypes in the DR region and thus...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/nature05133

Authors


Journal:
Nature More from this journal
Volume:
443
Issue:
7111
Pages:
574-577
Publication date:
2006-10-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Language:
English
Keywords:
Pubs id:
pubs:264757
UUID:
uuid:a79f820c-85e8-4b1d-a4a1-3f98b4e1dc57
Local pid:
pubs:264757
Source identifiers:
264757
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP