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Journal article

Isotype control of B cell signaling.

Abstract:

The B cell receptor (BCR) consists of an antigen-binding membrane immunoglobulin (mIg) associated with the CD79alpha and CD79beta heterodimer. Naïve B cells express the IgM and IgD isotypes, which have very short cytoplasmic tails and therefore depend on CD79alpha and CD79beta for signal transduction. After antigenic stimulation, B cells undergo isotype switching to yield IgG, IgE, or IgA. Recent research suggests that the ability of the B cell coreceptor CD22 to regulate BCR signaling depend...

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Publisher copy:
10.1126/stke.2003.184.pe21

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
Journal:
Science's STKE : signal transduction knowledge environment
Volume:
2003
Issue:
184
Pages:
pe21
Publication date:
2003-05-01
DOI:
EISSN:
1525-8882
ISSN:
1525-8882
Source identifiers:
26774
Language:
English
Keywords:
Pubs id:
pubs:26774
UUID:
uuid:a79f5c1e-4c3c-4519-81ab-3dec594f2fb3
Local pid:
pubs:26774
Deposit date:
2013-02-20

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