Journal article
Isotype control of B cell signaling.
- Abstract:
-
The B cell receptor (BCR) consists of an antigen-binding membrane immunoglobulin (mIg) associated with the CD79alpha and CD79beta heterodimer. Naïve B cells express the IgM and IgD isotypes, which have very short cytoplasmic tails and therefore depend on CD79alpha and CD79beta for signal transduction. After antigenic stimulation, B cells undergo isotype switching to yield IgG, IgE, or IgA. Recent research suggests that the ability of the B cell coreceptor CD22 to regulate BCR signaling depend...
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- Publisher copy:
- 10.1126/stke.2003.184.pe21
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Authors
Bibliographic Details
- Journal:
- Science's STKE : signal transduction knowledge environment
- Volume:
- 2003
- Issue:
- 184
- Pages:
- pe21
- Publication date:
- 2003-05-01
- DOI:
- EISSN:
-
1525-8882
- ISSN:
-
1525-8882
- Source identifiers:
-
26774
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:26774
- UUID:
-
uuid:a79f5c1e-4c3c-4519-81ab-3dec594f2fb3
- Local pid:
- pubs:26774
- Deposit date:
- 2013-02-20
Terms of use
- Copyright date:
- 2003
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