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A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis.

Abstract:
We conducted a trial of oral acetazolamide for the treatment of cryptococcal meningitis in 22 Thai adults with headache and an opening cerebrospinal fluid pressure of >/=200 mm H(2)0. The trial was terminated prematurely because patients who received acetazolamide developed significantly lower venous bicarbonate levels and higher chloride levels and had more-frequent serious adverse events than did subjects who received placebo.
Publication status:
Published

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Publisher copy:
10.1086/342299

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
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Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume:
35
Issue:
6
Pages:
769-772
Publication date:
2002-09-05
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
URN:
uuid:a79dc560-af06-4643-88c7-d06763994be2
Source identifiers:
8990
Local pid:
pubs:8990

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