A cross-species functional interaction between the murine major histocompatibility complex class I alpha 3 domain and human CD8 revealed by peptide-specific cytotoxic T lymphocytes.

Journal article

The monomorphic cell surface glycoprotein CD8 acts as co-receptor in the recognition of peptide-major histocompatibility complex (MHC) class I complexes by cytotoxic lymphocytes (CTL) by binding to the monomorphic alpha 3 domain of the class I molecule. Positions 227 and 245 in the class I alpha 3 domain appear to be especially important for this interaction. Recent reports suggest there is no interspecies recognition between CD8 and MHC class I. In this study, hybrid genes from human class I...

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Authors: Moots, R; Samberg, N; Pazmany, L; Frelinger, J; Mcmichael, A

• Publication status: Published
• Journal: European journal of immunology
• Volume: 22
• Issue: 6
• Pages: 1643-1646
• Publication date: 1992-06-01
• DOI: 10.1002/eji.1830220645
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Histocompatibility Antigens Class I; Flow Cytometry; Humans; Antigens, CD8; Cytotoxicity, Immunologic; Transfection; Mice; Animals; HLA-A Antigens; Cross Reactions; Cytotoxicity Tests, Immunologic; H-2 Antigens; Dose-Response Relationship, Immunologic; T-Lymphocytes, Cytotoxic