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Journal article

Genetic testing is important in families with a history suggestive of hereditary non-polyposis colorectal cancer even if the Amsterdam criteria are not fulfilled.

Abstract:

BACKGROUND: Clinical screening is still the first-line approach to identification of families with hereditary non-polyposis colorectal cancer (HNPCC). The need for uniformity of diagnosis of the syndrome, particularly in multicentre studies, led to the establishment of a set of minimum diagnostic criteria, the 'Amsterdam criteria'. It is now known that HNPCC is caused by germline defects in the human mismatch repair genes and DNA predictive testing is possible. Defects in two of the known mis...

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Publication status:
Published

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Journal:
British journal of surgery More from this journal
Volume:
84
Issue:
2
Pages:
233-237
Publication date:
1997-02-01
DOI:
EISSN:
1365-2168
ISSN:
0007-1323
Language:
English
Keywords:
Pubs id:
pubs:72319
UUID:
uuid:a798a9c1-b030-411e-8c87-08fdeec30cb4
Local pid:
pubs:72319
Source identifiers:
72319
Deposit date:
2012-12-19

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