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LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor.

Abstract:

The leukocyte integrin LFA-1 (CD11a/CD18) plays an important role in lymphocyte recirculation and homotypic interactions. Leukocytes from mice lacking CD11a displayed defects in in vitro homotypic aggregation, in proliferation in mixed lymphocyte reactions, and in response to mitogen. Mutant mice mounted normal cytotoxic T cell (CTL) responses against systemic LCMV and VSV infections and showed normal ex vivo CTL function. However, LFA-1-deficient mice did not reject immunogenic tumors grafte...

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Publication status:
Published

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Publisher copy:
10.1084/jem.183.4.1415

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Journal:
Journal of experimental medicine More from this journal
Volume:
183
Issue:
4
Pages:
1415-1426
Publication date:
1996-04-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Language:
English
Keywords:
Pubs id:
pubs:469260
UUID:
uuid:a796aa42-f427-4f09-a2e8-53b55e2d515c
Local pid:
pubs:469260
Source identifiers:
469260
Deposit date:
2014-06-17

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