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Journal article

Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas.

Abstract:

Clear-cut inherited Mendelian traits, such as familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer, account for <4% of colorectal cancers. Another 20% of all colorectal cancers are thought to occur in individuals with a significant inherited multifactorial susceptibility to colorectal cancer that is not obviously familial. Incompletely penetrant, comparatively rare missense variants in the adenomatous polyposis coli gene, which is responsible for familial adenomatous...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0407187101

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
101
Issue:
45
Pages:
15992-15997
Publication date:
2004-11-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:a7942623-6f4f-460c-b767-bce8889bb2a7
Source identifiers:
72225
Local pid:
pubs:72225

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