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Cellodextrin phosphorylase from Ruminiclostridium thermocellum: X-ray crystal structure and substrate specificity analysis

Abstract:

The GH94 glycoside hydrolase cellodextrin phosphorylase (CDP, EC 2.4.1.49) produces cellodextrin oligomers from short β-1→4-glucans and α-D-glucose 1-phosphate. Compared to cellobiose phosphorylase (CBP), which produces cellobiose from glucose and α-D-glucose 1-phosphate, CDP is biochemically less well characterised. Herein, we investigate the donor and acceptor substrate specificity of recombinant CDP from Ruminiclostridium thermocellum and we isolate and characterise a glucosamine addition ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.carres.2017.07.005

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Institution:
University of Oxford
Division:
MPLS
Department:
Plant Sciences
Role:
Author
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Grant:
InstituteStrategicProgramonUnderst
ExploitingMetabolism(MET)[BB/J004561/1
ing
John Innes Foundation More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Carbohydrate Research Journal website
Volume:
451
Pages:
118-132
Publication date:
2017-07-21
Acceptance date:
2017-07-17
DOI:
ISSN:
0008-6215
Keywords:
Pubs id:
pubs:709444
UUID:
uuid:a793eab9-1b7c-4818-8269-dee6cbb37589
Local pid:
pubs:709444
Source identifiers:
709444
Deposit date:
2017-07-27

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