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MAPK-specific tyrosine phosphatases: new targets for drug discovery?

Abstract:

Protein tyrosine phosphatases (PTPs) have key roles in a diverse range of cellular processes, and their dysregulation is associated with several human diseases. Many PTPs are recognized as potential drug targets; however, inhibitor development has focused only on a small number of enzymes, most notably PTP1B for type II diabetes and obesity, and MKP1 and CDC25 for cancer. The future challenge of selective-inhibitor development for PTPs will be significantly facilitated by the recent rapid pro...

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Publication status:
Published

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Publisher copy:
10.1016/j.tips.2006.08.005

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
Journal:
Trends in pharmacological sciences More from this journal
Volume:
27
Issue:
10
Pages:
525-530
Publication date:
2006-10-01
DOI:
EISSN:
1873-3735
ISSN:
0165-6147
Language:
English
Keywords:
Pubs id:
pubs:21873
UUID:
uuid:a788cc1a-4ad9-4d4c-a845-57811ddebfd4
Local pid:
pubs:21873
Source identifiers:
21873
Deposit date:
2012-12-19

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