- Abstract:
-
In this study we demonstrate that a disarmed version of the cytotoxin ricin can deliver exogenous CD8(+) T cell epitopes into the MHC class I-restricted pathway by a TAP-independent, signal peptidase-dependent pathway. Defined viral peptide epitopes genetically fused to the N terminus of an attenuated ricin A subunit (RTA) that was reassociated with its partner B subunit were able to reach the early secretory pathway of sensitive cells, including TAP-deficient cells. Successful processing and...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.4049/jimmunol.169.1.99
-
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- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 169
- Issue:
- 1
- Pages:
- 99-107
- Publication date:
- 2002-07-05
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:a7840a18-179c-4746-9bf5-98a86387cccb
- Source identifiers:
-
32132
- Local pid:
- pubs:32132
- Language:
- English
- Keywords:
- Copyright date:
- 2002
Journal article
Exogenous peptides delivered by ricin require processing by signal peptidase for transporter associated with antigen processing-independent MHC class I-restricted presentation.
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