- Abstract:
-
The BimEL tumor suppressor is a potent proapoptotic BH3-only protein. We found that, in response to survival signals, BimEL was rapidly phosphorylated on three serine residues in a conserved degron, facilitating binding and degradation via the F box protein betaTrCP. Phosphorylation of the BimEL degron was executed by Rsk1/2 and promoted by the Erk1/2-mediated phosphorylation of BimEL on Ser69. Compared to wild-type BimEL, a BimEL phosphorylation mutant unable to bind betaTrCP was stabilized ...
Expand abstract - Publisher copy:
- 10.1016/j.molcel.2008.12.020
-
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- Journal:
- Molecular cell
- Volume:
- 33
- Issue:
- 1
- Pages:
- 109-116
- Publication date:
- 2009-01-05
- DOI:
- EISSN:
-
1097-4164
- ISSN:
-
1097-2765
- URN:
-
uuid:a77ea84a-6f07-4fb1-80f9-01b640094990
- Source identifiers:
-
482587
- Local pid:
- pubs:482587
- Copyright date:
- 2009
Journal article
betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.
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