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betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.

Abstract:

The BimEL tumor suppressor is a potent proapoptotic BH3-only protein. We found that, in response to survival signals, BimEL was rapidly phosphorylated on three serine residues in a conserved degron, facilitating binding and degradation via the F box protein betaTrCP. Phosphorylation of the BimEL degron was executed by Rsk1/2 and promoted by the Erk1/2-mediated phosphorylation of BimEL on Ser69. Compared to wild-type BimEL, a BimEL phosphorylation mutant unable to bind betaTrCP was stabilized ...

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Authors


Bassermann, F More by this author
Guardavaccaro, D More by this author
Vasiliver-Shamis, G More by this author
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Journal:
Molecular cell
Volume:
33
Issue:
1
Pages:
109-116
Publication date:
2009-01-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:a77ea84a-6f07-4fb1-80f9-01b640094990
Source identifiers:
482587
Local pid:
pubs:482587

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