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Tissue-specific effects of sulfonylureas: lessons from studies of cloned K(ATP) channels.

Abstract:

Sulfonylureas stimulate insulin secretion in type-2 diabetic patients by blocking ATP-sensitive (K(ATP)) potassium channels in the pancreatic beta-cell membrane. This effect is mediated by the binding of the drug to the sulfonylurea receptor (SUR) subunit of the channel. K(ATP) channels are also present in other tissues, but often contain different types of SUR subunits (e.g., SUR1 in beta-cells, SUR2A in heart, SUR2B in smooth muscle). The sensitivity of these different types of K(ATP) chann...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Gribble, FM More by this author
Journal:
Journal of diabetes and its complications
Volume:
14
Issue:
4
Pages:
192-196
Publication date:
2000
DOI:
EISSN:
1873-460X
ISSN:
1056-8727
URN:
uuid:a77d2707-e8fe-448d-b617-de0beaed4a97
Source identifiers:
113853
Local pid:
pubs:113853

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