- Abstract:
-
Sulfonylureas stimulate insulin secretion in type-2 diabetic patients by blocking ATP-sensitive (K(ATP)) potassium channels in the pancreatic beta-cell membrane. This effect is mediated by the binding of the drug to the sulfonylurea receptor (SUR) subunit of the channel. K(ATP) channels are also present in other tissues, but often contain different types of SUR subunits (e.g., SUR1 in beta-cells, SUR2A in heart, SUR2B in smooth muscle). The sensitivity of these different types of K(ATP) chann...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s1056-8727(00)00081-7
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- Journal:
- Journal of diabetes and its complications
- Volume:
- 14
- Issue:
- 4
- Pages:
- 192-196
- Publication date:
- 2000
- DOI:
- EISSN:
-
1873-460X
- ISSN:
-
1056-8727
- URN:
-
uuid:a77d2707-e8fe-448d-b617-de0beaed4a97
- Source identifiers:
-
113853
- Local pid:
- pubs:113853
- Copyright date:
- 2000
Journal article
Tissue-specific effects of sulfonylureas: lessons from studies of cloned K(ATP) channels.
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