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Human immunization with a polymorphic malaria vaccine candidate induced antibodies to conserved epitopes that promote functional antibodies to multiple parasite strains

Abstract:

Background: Overcoming antigenic diversity is a key challenge in the development of effective Plasmodium falciparum malaria vaccines. Strategies that promote the generation of antibodies targeting conserved epitopes of vaccine antigens may provide protection against diverse parasites strains. Understanding differences between vaccine-induced and naturally acquired immunity is important to achieving this goal.

Methods: We analyzed antibodies generat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/infdis/jiy170

Authors


More by this author
Role:
Author
ORCID:
0000-0002-3605-038X
More by this author
Role:
Author
ORCID:
0000-0002-0268-232X
Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
218
Issue:
1
Pages:
35-43
Publication date:
2018-03-23
Acceptance date:
2018-03-22
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Pmid:
29584918
Language:
English
Keywords:
Pubs id:
1087444
Local pid:
pubs:1087444
Deposit date:
2021-09-27

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