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Glycosylated siglec6 expression in syncytiotrophoblast-derived extracellular vesicles from preeclamptic placentas

Abstract:
Preeclampsia (PE) is associated with an exaggerated maternal systemic inflammatory response. The placenta releases extracellular vesicles from its syncytiotrophoblast layer (STBEV) into the maternal circulation. Expression of Siglec6, a transmembrane receptor of molecular weight 50kDa, is known to be upregulated in PE placental lysate (PL). Here we investigate the abundance of Siglec6 in STBEV, and whether the levels are different between PE and normal STBEV.
Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Women’s & Reproductive Health
Role:
Author
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Name:
Wellcome Trust
Grant:
105605/Z/14/Z
Publisher:
Elsevier
Host title:
Placenta
Journal:
2018 International Federation of Placenta Associations Meeting (IFPA 2018) More from this journal
Volume:
69
Pages:
E77-E78
Publication date:
2018-09-10
DOI:
ISSN:
1532-3102 and 0143-4004
Pubs id:
pubs:921714
UUID:
uuid:a779a547-4b22-4c47-a5be-f587c3f2c36d
Local pid:
pubs:921714
Source identifiers:
921714
Deposit date:
2018-10-02

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