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Journal article

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals.

Abstract:

The threat of avian influenza A (H5N1) infection in humans remains a global health concern. Current influenza vaccines stimulate antibody responses against the surface glycoproteins but are ineffective against strains that have undergone significant antigenic variation. An alternative approach is to stimulate pre-existing memory T cells established by seasonal human influenza A infection that could cross-react with H5N1 by targeting highly conserved internal proteins. To determine how common ...

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Publication status:
Published

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Publisher copy:
10.1172/jci32460

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Journal:
The Journal of clinical investigation
Volume:
118
Issue:
10
Pages:
3478-3490
Publication date:
2008-10-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:a7727cb3-02f4-4973-a04e-9086a783abdf
Source identifiers:
31316
Local pid:
pubs:31316

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