Journal article
Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells.
- Abstract:
-
Previous studies have demonstrated that bispecific hybrid antibodies produced by cell-cell fusion or chemically conjugated heteroaggregates can direct cytotoxic T lymphocytes to kill target cells for which they have no intrinsic specificity, a phenomenon we call effector cell retargeting (ECR). These studies used bispecific reagents with one specificity directed to CD3 or Ti on the effector cell and the other directed to a target cell antigen. To avoid the need to create different hybrid hybr...
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- Publication status:
- Published
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- Publisher copy:
- 10.1073/pnas.85.20.7719
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Bibliographic Details
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 85
- Issue:
- 20
- Pages:
- 7719-7723
- Publication date:
- 1988-10-01
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Source identifiers:
-
15371
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:15371
- UUID:
-
uuid:a7683b51-36eb-4101-82d3-8647717ca9f6
- Local pid:
- pubs:15371
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1988
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