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Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells.

Abstract:

Previous studies have demonstrated that bispecific hybrid antibodies produced by cell-cell fusion or chemically conjugated heteroaggregates can direct cytotoxic T lymphocytes to kill target cells for which they have no intrinsic specificity, a phenomenon we call effector cell retargeting (ECR). These studies used bispecific reagents with one specificity directed to CD3 or Ti on the effector cell and the other directed to a target cell antigen. To avoid the need to create different hybrid hybr...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.85.20.7719

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
85
Issue:
20
Pages:
7719-7723
Publication date:
1988-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:a7683b51-36eb-4101-82d3-8647717ca9f6
Source identifiers:
15371
Local pid:
pubs:15371

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