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Gene type-specific control of pol II transcription elongation

Abstract:

Eukaryotic RNA polymerase II (RNA pol II) transcribes both protein-coding and snRNA genes. A hallmark of RNA pol II that distinguishes it from the other RNA polymerases is the unusual carboxy-terminal domain (CTD) of the large subunit. In mammals, the CTD comprises 52 repeats of the heptapeptide YSPTSPS. In the expression of protein-coding genes, phosphorylation of Ser2 of the CTD heptapeptide repeats by the positive transcription elongation factor b (P-TEFb) is associated with productive ...

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Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Name:
Ministry of Education, Saudi Arabia
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:a75fc9ff-64cc-48a6-a4f0-098a04e9a649
Deposit date:
2019-10-17

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