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Single arm NCRI phase II study of CHOP in combination with Ofatumumab in induction and maintenance for patients with newly diagnosed Richter’s syndrome

Abstract:

Background Transformation of B-cell chronic lymphocytic leukaemia (B-CLL) to diffuse large B cell lymphoma (DLBCL) (Richter’s syndrome (RS)) is a rare (2-15% of patients) but catastrophic complication of B-CLL. Dose-intense chemotherapy regimens investigated in small single institution trials, but with the exception of bone marrow transplantation for a minority of patients, little has improved the median overall survival of patients with RS beyond eight months. Patients ar...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12885-015-1048-9

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Name:
National Institute of Health Research
Publisher:
BioMed Central
Journal:
BMC Cancer More from this journal
Volume:
15
Issue:
1
Article number:
52
Publication date:
2015-02-13
Acceptance date:
2015-01-28
DOI:
EISSN:
1471-2407
ISSN:
1471-2407
Language:
English
Keywords:
Pubs id:
pubs:510418
UUID:
uuid:a75d65d2-a154-4176-bbab-c589f937a80f
Local pid:
pubs:510418
Source identifiers:
510418
Deposit date:
2015-11-03

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