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Intracellular antibody capture: A molecular biology approach to inhibitors of protein-protein interactions.

Abstract:

Many proteins of interest in basic biology, translational research studies and for clinical targeting in diseases reside inside the cell and function by interacting with other macromolecules. Protein complexes control basic processes such as development and cell division but also abnormal cell growth when mutations occur such as found in cancer. Interfering with protein-protein interactions is an important aspiration in both basic and disease biology but small molecule inhibitors have been di...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Lab Sciences
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Biochimica et biophysica acta Journal website
Volume:
1844
Issue:
11
Pages:
1970-1976
Publication date:
2014-11-01
DOI:
EISSN:
1878-1454
ISSN:
0006-3002
Source identifiers:
470657
Language:
English
Keywords:
UUID:
uuid:a759d0b2-f31b-4a52-a4a5-756364252757
Local pid:
pubs:470657
Deposit date:
2014-09-14

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