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Directed differentiation of dendritic cells from mouse embryonic stem cells.

Abstract:

Dendritic cells (DCs) are uniquely capable of presenting antigen to naive T cells, either eliciting immunity [1] or ensuring self-tolerance [2]. This property identifies DCs as potential candidates for enhancing responses to foreign [3] and tumour antigens [4], and as targets for immune intervention in the treatment of autoimmunity and allograft rejection [1]. Realisation of their therapeutic potential would be greatly facilitated by a fuller understanding of the function of DC-specific genes...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Journal:
Current biology : CB
Volume:
10
Issue:
23
Pages:
1515-1518
Publication date:
2000-11-01
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
Source identifiers:
21426

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