Directed differentiation of dendritic cells from mouse embryonic stem cells.
Dendritic cells (DCs) are uniquely capable of presenting antigen to naive T cells, either eliciting immunity  or ensuring self-tolerance . This property identifies DCs as potential candidates for enhancing responses to foreign  and tumour antigens , and as targets for immune intervention in the treatment of autoimmunity and allograft rejection . Realisation of their therapeutic potential would be greatly facilitated by a fuller understanding of the function of DC-specific genes...Expand abstract
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