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Journal article

Radiobiological determination of dose escalation and normal tissue toxicity in definitive chemoradiation therapy for esophageal cancer.

Abstract:

PURPOSE: This study investigated the trade-off in tumor coverage and organ-at-risk sparing when applying dose escalation for concurrent chemoradiation therapy (CRT) of mid-esophageal cancer, using radiobiological modeling to estimate local control and normal tissue toxicity. METHODS AND MATERIALS: Twenty-one patients with mid-esophageal cancer were selected from the SCOPE1 database (International Standard Randomised Controlled Trials number 47718479), with a mean planning target volume (PTV) ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More from this funder
Name:
Medical Research Council
Funding agency for:
Hawkins, M
Grant:
MC_PC_12001/2
More from this funder
Name:
Cancer Research UK
Funding agency for:
Warren, S
Partridge, M
Grant:
C5255/A15935
C5255/A15935
Publisher:
Elsevier
Journal:
International journal of radiation oncology, biology, physics More from this journal
Volume:
90
Issue:
2
Pages:
423-429
Publication date:
2014-10-01
DOI:
EISSN:
1879-355X
ISSN:
0360-3016
Language:
English
Keywords:
Pubs id:
pubs:486599
UUID:
uuid:a75602ba-f822-443e-aa4a-81ea724de1d9
Local pid:
pubs:486599
Source identifiers:
486599
Deposit date:
2015-10-16

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