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D-amino acid oxidase is expressed in the ventral tegmental area and modulates cortical dopamine.

Abstract:

D-amino acid oxidase (DAO, DAAO) degrades the NMDA receptor co-agonist D-serine, modulating D-serine levels and thence NMDA receptor function. DAO inhibitors are under development as a therapy for schizophrenia, a disorder involving both NMDA receptor and dopaminergic dysfunction. However, a direct role for DAO in dopamine regulation has not been demonstrated. Here, we address this question in two ways. First, using in situ hybridization and immunohistochemistry, we show that DAO mRNA and imm...

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Publisher copy:
10.3389/fnsyn.2014.00011

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
Publisher:
Frontiers Research Foundation
Journal:
Frontiers in synaptic neuroscience More from this journal
Volume:
6
Issue:
MAY
Pages:
11
Publication date:
2014-01-01
DOI:
EISSN:
1663-3563
Language:
English
Keywords:
Pubs id:
pubs:464918
UUID:
uuid:a75293b7-ea8c-4710-bfbc-19fb0ea13e98
Local pid:
pubs:464918
Source identifiers:
464918
Deposit date:
2014-06-17

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