Journal article icon

Journal article

The human muscle proteome in aging.

Abstract:
The aim of the present study was to assess age-dependent changes of proteins in the vastus lateralis muscle of physically active elderly and young subjects by a combination of two-dimensional difference gel electrophoresis, SDS-PAGE and ESI-MS/MS. The differences observed in the elderly group included down-regulation of regulatory myosin light chains, particularly the phosphorylated isoforms, a higher proportion of myosin heavy chain isoforms 1 and 2A, and enhanced oxidative and reduced glycolytic capacity.
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1021/pr050414x

Authors


Ripamonti, M More by this author
Pontoglio, A More by this author
Expand authors...
Journal:
Journal of proteome research
Volume:
5
Issue:
6
Pages:
1344-1353
Publication date:
2006-06-05
DOI:
EISSN:
1535-3907
ISSN:
1535-3893
URN:
uuid:a751b3a6-8756-45a0-890b-65993b50e16b
Source identifiers:
229696
Local pid:
pubs:229696

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP