- Abstract:
- The aim of the present study was to assess age-dependent changes of proteins in the vastus lateralis muscle of physically active elderly and young subjects by a combination of two-dimensional difference gel electrophoresis, SDS-PAGE and ESI-MS/MS. The differences observed in the elderly group included down-regulation of regulatory myosin light chains, particularly the phosphorylated isoforms, a higher proportion of myosin heavy chain isoforms 1 and 2A, and enhanced oxidative and reduced glycolytic capacity.
- Publication status:
- Published
- Publisher copy:
- 10.1021/pr050414x
-
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- Journal:
- Journal of proteome research
- Volume:
- 5
- Issue:
- 6
- Pages:
- 1344-1353
- Publication date:
- 2006-06-05
- DOI:
- EISSN:
-
1535-3907
- ISSN:
-
1535-3893
- URN:
-
uuid:a751b3a6-8756-45a0-890b-65993b50e16b
- Source identifiers:
-
229696
- Local pid:
- pubs:229696
- Copyright date:
- 2006
Journal article
The human muscle proteome in aging.
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